Detalhe da pesquisa
1.
Characterization of GEXP15 as a Potential Regulator of Protein Phosphatase 1 in Plasmodium falciparum.
Int J Mol Sci
; 24(16)2023 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37628837
2.
SINAPs: A Software Tool for Analysis and Visualization of Interaction Networks of Molecular Dynamics Simulations.
J Chem Inf Model
; 62(6): 1425-1436, 2022 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35239339
3.
In vitro and in silico approach to study the hormonal activities of the alternative plasticizer tri-(2-ethylhexyl) trimellitate TEHTM and its metabolites.
Arch Toxicol
; 96(3): 899-918, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35089383
4.
Polycyclic nitrogen heterocycles as potential thymidine phosphorylase inhibitors: synthesis, biological evaluation, and molecular docking study.
J Enzyme Inhib Med Chem
; 37(1): 252-268, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34933639
5.
Ultrasounds-mediated 10-seconds synthesis of chalcones as potential farnesyltransferase inhibitors.
Bioorg Med Chem Lett
; 30(11): 127149, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32247731
6.
Indolizine-phenothiazine hybrids as the first dual inhibitors of tubulin polymerization and farnesyltransferase with synergistic antitumor activity.
Bioorg Chem
; 103: 104184, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32891861
7.
Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands.
Bioorg Chem
; 96: 103643, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32035298
8.
New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease.
Neurobiol Dis
; 129: 217-233, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30928644
9.
In vitro and in silico hormonal activity studies of di-(2-ethylhexyl)terephthalate, a di-(2-ethylhexyl)phthalate substitute used in medical devices, and its metabolites.
J Appl Toxicol
; 39(7): 1043-1056, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30847963
10.
Exploring isoxazoles and pyrrolidinones decorated with the 4,6-dimethoxy-1,3,5-triazine unit as human farnesyltransferase inhibitors.
Arch Pharm (Weinheim)
; 352(5): e1800227, 2019 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-30947375
11.
On the discovery of new potent human farnesyltransferase inhibitors: emerging pyroglutamic derivatives.
Org Biomol Chem
; 15(38): 8110-8118, 2017 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28905970
12.
New indolizine-chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation.
Bioorg Med Chem Lett
; 26(15): 3730-4, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27282741
13.
Synthesis and biological evaluation of thiophene and benzo[b]thiophene analogs of combretastatin A-4 and isocombretastatin A-4: A comparison between the linkage positions of the 3,4,5-trimethoxystyrene unit.
Bioorg Med Chem Lett
; 26(1): 174-80, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26602281
14.
Methylene versus carbonyl bridge in the structure of new tubulin polymerization inhibitors with tricyclic A-rings.
Bioorg Med Chem
; 24(22): 6021-6030, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27707624
15.
Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents.
Bioorg Med Chem
; 24(10): 2307-17, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27073050
16.
Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate.
J Enzyme Inhib Med Chem
; 31(3): 448-55, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-25942360
17.
Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of CD1d-glycolipids dynamics simulations.
PLoS Comput Biol
; 10(11): e1003902, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25376021
18.
Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds.
Bioorg Med Chem Lett
; 25(20): 4447-52, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26372651
19.
Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase.
Bioorg Med Chem Lett
; 24(24): 5777-5781, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453818
20.
Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase.
Bioorg Med Chem Lett
; 24(14): 3180-5, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24856060